Location: analytical pharmaceutical chemistry research unit of the Geneva-Lausanne School of pharmaceutical sciences, Geneva, Switzerland
Title: Evaluation of supercritical fluid chromatography (SFC) and its coupling with mass spectrometry (MS) for pharmaceutical analysis.
The goal of this PhD work is to evaluate the possibilities of supercritical fluid chromatography (SFC) in the pharmaceutical analysis. This chromatographic approach will be used to develop analytical methods for numerous types of drugs (including chiral ones) in pharmaceutical formulations. Some inventive strategies will be developed to maximize performance and apply SFC to the widest possible range of molecules. The performance of SFC will be systematically compared to liquid chromatography (LC). In parallel, the PhD candidate will also have the opportunity to couple SFC with single quadrupole(MS), triple quadrupole (MS/MS) and high resolution (QqTOF/MS) mass spectrometers available in our laboratory. This instrumental setup will be used for the determination of drugs and metabolites in complex matrixes, such as biological fluids.
Start: 1st of January 2018 Duration: 4 years
Supervision: Prof. Jean-Luc Veuthey, Dr Davy Guillarme
Salary: The salary will follow the Geneva-Lausanne School of Pharmacy standards.
Requirements: The candidate holds a master degree in pharmaceutical sciences, pharmacy, or an equivalent degree. The ideal candidate is highly motivated, team player, well organized, French speaking, and has good oral and written communication skills
in English. Good knowledge in chromatography and/or mass spectrometry will be an asset. The PhD student will have a position of part-time assistant. He/she will participate to teaching activities for undergraduate students.
If you are interested by the position, please send your CV, cover letter, recommendation letter(s) and academic grades of the last two years to Dr Davy Guillarme (firstname.lastname@example.org) before the 30th of September 2017.